人白细胞抗原-B27在诊断强直性脊柱炎中的意义

Clinical significance of HLA-B27 test in diagnosis of ankylosing spondylitis

目的探讨人白细胞抗原-B27(HLA-B27)检测诊断强直性脊柱炎(AS)的意义。方法应用ELISA法,对107例AS患者、70例类风湿性关节炎(RA)患者及100例健康体检者进行HLA-B27对比检测。结果AS组HLA-B27阳性率为92.5%,RA组阳性率为7.1%,体检组阳性率为3.0%,AS组明显高于RA组和体检对照组,差异有统计学意义(χ2=214,P<0.01)。男性HLA-B27阳性率(49.7%)明显高于女性(14.8%),差异有统计学意义(χ2=30.9,P<0.01)。不同年龄组HLA-B27阳性率有明显差异,30岁以下年龄组明显高于其他年龄组。结论HLA-B27与AS具有很强的相关性,检测HLA-B27对于AS的早期诊断和鉴别具有重要意义。

Objective To explore the clinical significance of HLA-B27 test in diagnosis of ankylosing spondylitis （AS）. Methods The concentration of HLA-B27 was detected by ELISA in 107 AS patients, 70 RA patients and 100 healthy individuals. The results were compared. Results The HLA-B27 positive rate of AS group, RA group and healthy control group was 92.5 %, 7.1 % and 3.0 % respectively, and there was significant difference （χ^2= 214, P〈0.01）. The positive rate of HLA-B27 in male group and female group was 49.7% and 14.8% respectively （χ^2 = 30.9,P〈0.01）. There was a signficant difference in different age groups. The positive rate of HLA-B27 in age 30 below was significantly higher than that in the other groups. Conclusion HLA-B27 is closely associated with ankylosing spondylitis, and HLA-B27 detection contributes to early diagnosis and differential diagnosis of ankylosing spondylitis.