表位疫苗研究进展

Progress of Epitope Vaccine

表位疫苗是用抗原表位制备的疫苗,是近年来新兴的一种疫苗研制技术,也是今后最具开发前景的疫苗技术之一,在肿瘤、病毒等疾病的防治中有着自身独特的优势。详细阐述了T表位和B表位的筛选和鉴定方法、表位疫苗的载体研究及表位疫苗在肿瘤、病毒和微生物感染中的应用等,对表位疫苗的最新研究进展进行了综述。

Epitope vaccine is one of the emerging vaccine techniques developing in past decade years. Particularly the advantages of this vaccine on preventing and therapy illness, as cancer and virus, are espacially outstanding. The most importent elements about the vaccine, namely T/B-epitopes obtainment and identification, vehicles for epitope and vaccine construction, are reviewed. In addition, applications of the vaccine technique in some refractory diseases, such as cancer ,virus and pathogen infection ,are depicted.