肝血管瘤37例立体定向适形放射治疗临床分析

Stereotactic conformal radiotherapy for 37 patients with hemangioma:Clinical analysis

目的探讨立体定向适形放射治疗肝血管瘤的临床效果。方法回顾性分析笔者所在医院1999-05～2005-11对37例肝血管瘤患者39个病灶进行立体定向适形放射治疗的资料。男20例,女17例;年龄31～68岁,中位年龄46岁。肿瘤直径4.0～23.0cm,平均7.6cm;病灶边缘剂量28～35Gy,平均32Gy;分割剂量1.5～5Gy,平均为4Gy。治疗后9～12个月评价其治疗效果。结果经9～79个月(平均28.2个月)的随访,39个肝血管瘤病灶中完全消失者为30个病灶(76.9%),部分消失者为9个病灶(23.1%)。临床症状消失的为30例(81.1%),减轻为5例(13.5%),无效2例(5.4%)。急性造血系统和胃肠道反应轻微,未发现其它不良反应。结论立体定向适形放射治疗肝血管瘤是安全有效的方法之一,能改善临床症状,无严重毒副作用,患者耐受良好,远期并发症有待进一步观察。

Objective To evaluate the clildeal effect of slereolaetie eonformal radiolherapy for hemangioma. Metbods Thirty-nine tumor targets of thity-seven palients with hemamgioma had been treated from june 1999 to Noyember 2005;there were 20 males and 17 females, mean age 46yr （31- 68yr）.The diameler of lira lesions ranged 4.0-23.0era（mean 7.6cm）. The marginal dose ranged from 28 to 35Gy（mean 32Gy）.The fractional dose was 1.5-5Gy （mean 4.0Gy）.Results The tlierapeutie efficacy was evahmled later 9-12 months after stereotactle conformal radiotheralpy.Through the foiling-up period of 9- 79（58.2）molllhs, 30 of total 39 hemangiomas of liver complelely disappeared （76.9%）,9 parlially relieved （23.1%）.Clinieal symplons were eompetely relieved after trcalmenl in 30 palienls （81.1%）,improved in 5 patlenls （13.5%）, been ineffeetive in 2 patieilts.The aelite hemalologleal toxielties （such us leukemia） and gaslroinlestinal loxicities were slight and Ho other servious complications were found.Conclusion Abovementioned method is one of the safe and effective treatmeats.lt can revelive clinical symptons and well tolerated with no severe side effects,The effects .The long compliations remain further to be sudied.