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抑癌基因PTEN在肿瘤发生发展中的作用 被引量:5

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出处 《安徽医药》 CAS 2007年第11期963-964,共2页 Anhui Medical and Pharmaceutical Journal
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参考文献14

  • 1Li DM,Sun H.TEP1,encoded by a candidate tumor suppressor locus,is a novel protein tyrosine phosphatase regulated by transforming growth factor β[J].Cancer Bes,1997,57:2124-9.
  • 2杨震,孙国平.抑癌基因PTEN与原发性肝癌的研究进展[J].安徽医药,2006,10(2):85-87. 被引量:4
  • 3Wang L,Wang W,Zhang Y,et al.Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma[J].Hepatol Res,2007,37(5),389-6.
  • 4Cantley LC,Neel BG.New insight into tumor suppression:PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway[J].Proc Natl Acad Sci USA,1999,96:240-5.
  • 5Cheong JW,Eom JI,Maeng HY,et al.Phasphatase and tensin homologue phosphorylation in the C-terminal regulatory domain is frequently observed in acute myeloid leukaemia and aasocimed with poor clinical outcome[J].British Journal of Haematoiogy,2003,122:454-6.
  • 6Koul D,Parthasarathy R,Shen R,et al.Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN[J].Oncogene,2001,20:6669-78.
  • 7Erkanli S,Kayaselcuk F,Kuscu E,et al.Expression of survivin,PTEN and p27 in normal,hyperplastic,and carcinomatous endometrium[J].Int J Gynecol Cancer,2006,16:1412-8.
  • 8谢思明,沈丽佳,殷操,阮萍,姚希.抑癌基因PTEN与PIP3、细胞周期蛋白D1在口腔鳞癌中的表达及其相关性分析[J].中华口腔医学杂志,2006,41(7):407-410. 被引量:11
  • 9Tian XX,Zhang YG,Du J,et al.Effects of cotransfection of antisense-EGFR and wild-type PTEN cDNA on human glioblastoma cells[J].Neuropathology,2006,26:178-87.
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二级参考文献39

  • 1沈丽佳,谢思明,殷操,阮萍,姚希.抑癌基因PTEN和FHIT在口腔鳞癌中的表达及其与cyclin D1的相关性[J].第一军医大学学报,2005,25(1):79-82. 被引量:14
  • 2杨志芳,易继林,李兴睿,谢大兴,廖晓锋.PTEN依赖其磷酸酶活性诱导肝癌细胞发生失巢凋亡机制的探讨[J].中华肿瘤杂志,2005,27(5):273-275. 被引量:10
  • 3Fujiwara Y,Hoon DS,Yamada T,et al.PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinoma.Jpn J Cancer Res,2000,91(3):287-92.
  • 4Yu J,Ni M,Xu J,et al.Methylation profiling of twenty promoter CpG island of genes which may contribute to hepatocellular carcinogenesis.BWC Cancer,2002,2(29):1471-2407
  • 5Zhang L,Yu Q,He J,Zha X.Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines.Mol Cell Biochem,2004,262(1-2):25-33.
  • 6Horie Y,Suzuki A,Kataoka E,et al.Hepatocyte-specific Pten deficiency results in steatohepatitis and hepacellular carcinomas.Clin Invest,2004,113(12):1774-83.
  • 7Yeh KT,Chang JG,Chen YJ.Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma.Cancer Invest,2000,18(2):123-9.
  • 8Yao YJ,Ping XL,Zhang H,et al.PTEN/MMAC1 mutations in hepatocellular carcinomas.Oncogene,1999,18(20):3181-5.
  • 9Ginn-Pease ME,Eng C.Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF27 cells.Cancer Res,2003,63(2):282-6.
  • 10Moom S K,Kim H M,Kim C H.PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-kappa B and AP-1 in vascular smooth muscle cells.Arch Biochem Biophys,2004,421(2):267-76.

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