晶状体随年龄增长对眼前段轴向空间结构的影响

Effect of Lens Increasing with Age on Vertical Space in Anterior Segment of Normal Eyes

【目的】探讨正常人晶状体随年龄的增长对眼前段轴向空间结构的影响。【方法】采用眼前段光学相干断层扫描仪(AS-OCT)测量正常人105例(105只眼)前房深度(ACD)和晶状体厚度(LT);比较它们性别间的差异,采用直线相关与回归分析方法分析年龄与ACD、LT的相关关系。【结果】正常人ACD、LT的平均值分别为:2.97(S=0.32)mm、4.21(S=0.43)mm。女性ACD为2.87(S=0.33)mm比男性3.07(S=0.29)mm浅(P=0.001);LT性别间差异无统计学意义(P=0.250)。ACD与年龄负相关(r=-0.570,P=0.000),LT与年龄正相关(r=0.806,P=0.000)。ACD随年龄的增加每年变浅8μm(P=0.000);LT随年龄每年增厚21μm(P=0.000)。晶状体随年龄向玻璃体腔方向扩张的速度存在性别差异(P=0.000),男性13μm/year,女性7μm/year。【结论】女性ACD比男性浅,正常人随着年龄的增加,ACD逐渐变浅,LT厚度逐渐增加。女性LT的增加使ACD更趋于变浅,而男性则较多向玻璃体腔扩张。

[Objective] To evaluate effect of lens increasing with ages on the vertical space of anterior segment in normal subjects. [Methods] One hundred and five eyes of 105 normal subjects were enrolled, whose anterior chamber depth （ACD） and lens thickness （LT） were measured using anterior segment optical coherence tomography （AS-OCT）. The differences of ACD and LT between genders were compared. The effect of age on ACD and LT were analyzed using linear correlation and regression. [Results] The mean of ACD and LT were 2.97 （S= 0.32） mm, 4.21 （S=0.43） mm, respectively. The mean ACD of females was 2.87 （S=0.33） mm, which was significantly shallower than that of males 3.07 （S=0.29） mm （P=0.001）. LT showed no significant difference between genders （P=0.250）. There were significant negative correlation between age and ACD （r=-0.570, P=0.000）, and positive relationship between age and LT （r=0.806, P=0.000）. The linear analysis showed decreases of ACD with age（P=0.000）by 8 μm per year, and the increase of LT with age（P=0.000）by 21 （m per year, respectively. The tendency of lens growth with age toward vitreous cavity was more apparent in males than in females （P=0.000）, which was 13 μm in males and 7 μm in females per year. [Conclusion] The ACD of females was shallower than that of males. In normal subjects, ACD become shallower while LT increase with age. The increase of LT in females was prone to narrowing ACD, while the growth of lens in males was much likely towards vitreous cavity.