核因子-κB介导危重新生儿免疫功能研究

Nuclear Factor Kappa B Involed in Immunologic Function of Critically Ill Newborns

目的观察危重新生儿危重状态下免疫功能改变及核因子-κB(NF-κB)在其中的作用。方法选择50例危重新生儿作为观察对象,25例健康新生儿作为健康对照组。抽取二组静脉血,分别检测其血IL-4、IFN-γ、TNF-α及NF-κB等免疫指标。结果与健康对照组比较,危重新生儿存在NF-κB活性增高及Th1及Th2平衡紊乱,IL-4及TNF-α显著升高,IFN-γ降低。结论危重新生儿存在免疫功能紊乱;NF-κB信号转导通路参与危重新生儿发病。

Objective To observe the immunologic function of critically ill newborn and the relative function of nuclear factor kappa B （ NF - κB）. Methods The critically ill group contained 50 cases, and 25 cases from healthy newborns were used as control group. Blood samples were collected in each case,levels of cytokine interleukin （IL） - 4, interferon （IFN） -γ, tumor necrosis factor（TNF） - α and NF -κB were detected. Result Compared with control group, NF -κB of the critically ill newborn activated and the cytokine were disorder, and IL -4 and TNF- α increased, but IFN - γ decreased. Conclusions Critically ill newborn exist immune functional disorder. Furthermore, NF - κB activation may be involved in the process in infants with critically illness.