摘要
目的对毛细支气管炎患儿280例3~10 a随访,观察其日后支气管哮喘的发生率。方法采用回顾性研究和临床随访方法,选择1995年1月-2002年12月确诊为毛细支气管炎在本科住院治疗患儿280例为研究对象。男220例,女60例。就是否进行大剂量静脉用免疫球蛋白（IVIG）治疗、是否按时接种卡介苗（BCG）、喂养方式、哮喘家族史及有无过敏性体质等调查和分析。结果毛细支气管炎患儿280例中,发展成支气管哮喘82例,发生率为29.29%。大剂量IVIG组、按时接种BCG组、无过敏性体质患儿、无哮喘家族史患儿及母乳喂养儿哮喘发生率均显著低于非大剂量IVIG组、未按时接种BCG组、过敏性体质患儿、哮喘家族史患儿及非母乳喂养儿（Pa〈0.01）。结论婴幼儿毛细支气管炎易发展为支气管哮喘。过敏性体质和哮喘家族史是哮喘发生、发展高危因素,而大剂量IVIG治疗、及时接种BCG及单纯母乳喂养对哮喘发生呈保护作用。
Objective To observe the incidence of bronchial asthma thereafter by 3 to 10 years＇ follow - up of 280 children with bronchiolitis and analyze the correlation factors affecting the development of asthma. Methods Two hundred and eighty children with bronchitis were chosen and treated from Jan. 1995 to Dec. 2002,220 males, and 60 females. The review research and clinical revisits were carried out to investigate and analyze the subjects in terms of whether receiving large dose of intravenous injection immunoglobulin（IVIG） treatment or not ,whether getting vaccinated with bacille cahnette guerin（BCG） as planed or not, whether having asthma family history and the allergic physique or not, the way of feeding, and so on. Results The rate of asthma was 29.29% （82/280）, and the incidence of asthma was significantly lower in children with administering the large dose of IVIG,vaccinating BCG vaccine as planed, having no allergic physique, having no asthma family history or breast feeding than those without administering the large dose of IVIG ,vaccinating BCG vaccine as planed ,brest feeding ,with allergic physique, asthma family history（ Pa 〈 0.01 ）. Conclusions Children with bronchiolitis during infants and young children period are liable to asthma. Allergic physique and asthma family history are high risk factors leading to the development and occurrence of asthma;while large dose of IVIG treatment,BCG vaccination as planed and breast feeding only may take on protection against the occurrence of asthma.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第21期1646-1647,1649,共3页
Journal of Applied Clinical Pediatrics
