毛细支气管炎与儿童哮喘相关性

Correlation between Bronchiclitics and Asthma in Children

目的探讨毛细支气管炎患儿继发儿童哮喘的高危因素。方法对102例住院治疗的毛细支气管炎患儿病史进行分析,坚持2-7a的随防观察,就患儿性别、发病年龄、喂养方式、病情严重度、特应性体质、家族过敏和（或）哮喘病史、环境暴露、被动吸烟等因素对日后继发儿童哮喘的影响进行Logistic回归分析。结果毛细支气管炎患儿102例转为儿童哮喘47例（46.08%）,显著高于国内城区普查数据（0.12%-3.34%）。多变量Logistic回归分析显示,环境暴露（OR6.099,95%CI1.824-20.396）、被动吸烟（OR49.222,95%CI8.219-294.774）、患儿特应性体质（OR45.548,95%CI6.799-305.117）、家族过敏和（或）哮喘病史（OR47.921,95%CI8.626-266.226）与继发哮喘显著相关（Pa〈0.01）。结论毛细支气管炎患儿的生活环境、被动吸烟、特应性体质及家族过敏和（或）哮喘病史等均为其日后继发儿童哮喘的重要影响因素,可作为毛细支气管炎预后干预治疗的临床依据。

Objective To explore the risk factors of asthma in children with bronchielitics. Methods One hundred and two cases hospitalized patients with bronehiolitis were analyzed and followed - up for 2 - 7 years, items of follow - up included sex, morbidity age, food feeding, severity of disease, atopy physique, family history of atopy/asthma, environment exposure, passive smoking, and so on. The factors were carried on the Logistic regression analysis to determine the influence on later years to having recurrent asthma. Results Forty - seven cases had transferred asthma,which was remarkably higher than the domestic urban survey data（0.12% - 3.34% ）. The muhi - factors Logistic regression analysis demon- strated that environment（ OR 6. 099,95% CI 1. 824 - 20. 396 ）, passive smoking（ OR 49. 222,95% CI 8. 219 - 294. 774 ） , atopy physique （ OR 45. 548,95 % CI 6. 799 - 305.117 ） and family history of atopy/asthma （ OR 47.921,95 % CI 8. 626 - 266. 226 ） were the risk facter of asthma （ Pa 〈 0.01 ）. Conclusion The living condition, passive smoking, atopy physique and family history of atopy/asthma of children with bronchiolitis are important correlative factors of asthma recurrent in later years.