自由基清除剂依达拉奉治疗脑出血36例疗效观察

Oberservation of free radical scavenger edaravone on cerebral hemorrhage

目的了解自由基清除剂依达拉奉在脑出血急性期中的治疗作用。方法36例脑出血患者随机分为治疗组、对照组,治疗组在常规治疗基础上,给予依达拉奉治疗,采用神经功能缺损评分(european stroke score,ESS)和日常生活活动量表评分(activity of daily living scale,ADL)观察两组患者发病第1、2、4周时神经功能及日常生活活动能力恢复情况。结果治疗后1、2、4周,治疗组ESS及ADL评分均显著高于对照组(P<0.01)。结论自由基损伤在脑出血后脑组织损伤占有重要作用。脑出血急性期使用依达拉奉能有效改善脑出血患者的神经功能缺失和日常生活能力,是一种有效、安全的神经保护剂,可在出血性脑血管病的治疗中推广应用。

Objective To observe the clinical efficacy of free radical scavenger edaravone on cerebral hemorrhage. Methods Thirty-six cerebral hemorrhage patients were randomly selected and assigned to treatment group and control group. Edaravone was added to treat on the patients of treatment group respectively. ESS and ADL were adoped to evaluate the efficacy of edaravone on 1 ,2 , 4 week after treatment. Results There were significant differences between treatment group and control group on 1,2,4 weeks after treatment. Conclusion Free radical scavenger edaravone can advanced the recovery of neural function and activity of daily living. It is a effective and safe drug to the treatment of cerebral hemorrhage.