Rh阴性血型同胞间半相合造血干细胞移植治疗慢性粒细胞白血病临床研究

Clinical investigation on hematopoietic stem cell transplantation with haploidentical sibling donor but Rh negative blood type for patient with CML

目的总结国内首例Rh阴性血型同胞间半相合造血干细胞移植经验。方法对1例53岁慢性粒细胞白血病慢性期女性患者实施同胞间半相合造血干细胞移植(外周血干细胞加骨髓干细胞混合移植),观察造血重建及移植相关并发症。结果患者ANC>0.5×109/L,PLT>20×109/L的时间分别为+15d,+18d;染色体检查提示有XY染色体;+39d内未观察到急性移植物抗宿主病、肝静脉闭塞病、肝肾功能损伤等移植并发症。结论半相合造血干细胞移植可解决供者来源困难,是治疗慢性粒细胞白血病的有效手段。

Objective To summarize the experience on the first case of hematopoietic stem cell transplantation （HSCT） with haploidentical sibling donor but Rh negative blood type. Methods A 52 years old female patient, with chronic myelogenous leukemia in chronic phase （CML-CP）, received mix-HSCT（peripheral blood stem cells and bone marrow stem cells） with haploidentical sibling donor but Rh negative blood type. The hematopoietic reconstitution and complications correlated with HSCT were observed. Results The days for reaching of neutrophil〉0.5×10^9/L and platelet〉20×10^9/L were ＋15d and ＋18d, respectively. It was identified that the sex chromosome was XY after transplantation, besides, no complications happended within＋39d,including acute graft versus host disease, venous occlusion disease, hepatic and renal function damage, and so on. Conclusion HSCT with haploidentical donor may make up the insufficiency of donors, and it is confirmed to be an effective therapeutic option for CML patients.