摘要
目的观察放/化疗加APBSCT治疗NK/T细胞淋巴瘤鼻型的疗效。方法用CHOP+Lasp方案1个疗程、CHOP(或MOED、COED)+HD-MTX方案化疗2~3个疗程,行干细胞动员、采集,CEAC方案预处理及APBSCT及移植后局部病灶的放疗;病程中共行3次鞘内注射化疗药,6~8次联合化疗。结果Ⅰ~Ⅱ期患者移植后1年生存率55.6%(5/9例),2年生存率为44.4%(4/9例);Ⅲ~Ⅳ期患者移植后3个月~1年内由CR到病情复发,死亡4例,2年生存率为0。结论NK/T细胞淋巴瘤鼻型分期晚的治疗效果差,大剂量化/放疗+APBSCT治疗NK/TCL可能是有效的措施之一。
Objective To observe the therapeutic effect for treatment of extranode nasal-type NK/T cell lymphoma with APBSCT combined with radiotherapy and chemotherapy. Methods After 1 course of CHOP+ Laspl chemotherapy and 2 courses of CHOP(or MOED.COED)+HD-MTX chemotherapy, to mobilize and collecte the stem cells, and then use CEAC chemotherapy for pretreatment. During the therapeutic period, 3 times' intrathecal injection chemotherapy and 6--8 chemotherapies were needed, and after transplantation, the local lesion's radiotherapy was needed. Results One year survival rate of Ⅰ -Ⅱ phase patients was 55.6%(5/9), two year survival rate of Ⅰ -Ⅱ phase patients was 44.4%(4/9). Patients in Ⅲ - Ⅳ phases usually relapsed in 1 year and 4 patients died, the two year survival rate was 0. Conclusion NK/T cell lymphoma in advanced stage always has poor therapeutic effect, the APBSCT combined with high-dose chemotherapy and radiotherapy may be an effective treatment for the disease.
出处
《重庆医学》
CAS
CSCD
2007年第17期1697-1698,共2页
Chongqing medicine
基金
重庆市医学重点学科建设基金资助项目(2006C028)。
关键词
结外NK/T细胞淋巴瘤鼻型
化疗
放疗
自体外周造血干细胞移植
extranode nasal-type NK/T cell lymphoma
chemotherapy
radiotherapy
autologous peripheral blood stem cell transplantation (APBSCT)