脑白质疏松与脑血管病关系的临床研究

Study on the relationship between leukoaraiosis and cerebrovascular diseases

目的探讨脑白质疏松(LA)与脑血管疾病,尤其是与缺血性脑血管疾病的关系。方法选取我院经MRI检查确诊为脑血管疾病和LA的患者各277例和198例,分析脑血管病患者中不同年龄段LA的发生率、不同类型脑血管病患者中LA的发生率和LA患者中不同类型脑血管病的发生率。结果脑血管患者中LA的发生率随年龄的增长而增加,年龄是LA的独立危险因素,其影响远高于脑血管病对LA发生率的影响;脑出血患者中LA的发生率为30.30%,脑缺血患者中LA的发生率为48.8%;LA患者中发生出血性脑血管病占5.1%,发生缺血性脑血管病占60.1%;47例LA合并腔隙梗塞患者中,基底节梗塞率最高,为63.8%。结论LA的存在可以看作是梗塞发作的预兆,临床上须认识到LA作为中风先兆的重要性。

Objective To explore the relation of leukoaraiosis （LA） with cerebrovascular diseases, especially ischemic cerebrovascular diseases. Methods A total of 277 and 198 patients, who were hospitalized in our hospital and definitely diagnosed by MRI as cerebrovascular diseases and LA respectively, were recruited in this study. The incidence of LA in patients with cerebrovascular diseases at different ages was analyzed; the incidence of LA in patients with cerebrovascular diseases of different types and the incidence of cerebrovascular diseases of different types in patients with LA were comparatively analyzed. Results The LA incidence in patients with cerebrovascular diseases rose with the increasing of age, so age is an independent risk factor for LA, whose impact on the LA incidence is much greater than that of cerebrovascular diseases; the incidences of LA in patients with cerebral hemorrhage and cerebral ischemia were respectively 30.3% and 48.8%; the incidences of hemorrhagic and ischemic cerebrovascular diseases in patients with LA were respectively 5.1% and 60.1%; the incidence of infarction in basal ganglia regions in the 47 cases suffering from LA with lacuna infarction was 63.8%, namely the highest occurrence rate. Condusion The presence of LA can be regarded as a predictor of infarction. LA should be taken into account clinically as a potential predictor of stroke.