摘要
目的比较非酒精性脂肪肝患者性别之间生化代谢差异,探讨预防控制策略。方法检测973名体检者的总蛋白(TP)、白蛋白(ALB)、球蛋白(GLO)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、葡萄糖(GLU)、总胆固醇(T-CHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apoA1)、载脂蛋白B100(apoB100),计算non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、TC/HDL-C比值,并对89例非酒精性脂肪肝与202名体检健康者(对照组)进行比较。结果脂肪肝患病率为9.05%,男性患病率12.53%,显著高于女性的6.0%(P〈0.05);与对照组比较,59例男性患者的ALT、IBIL、TG、HDL-C、LDL-C、apoA1、non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、TC/HDL—C差异有统计学意义(P〈0.05,P〈0.01).30例女性患者的AST、TBIL、DBIL、IBIL、GLU、T-CHO、TG、LDL—C、apoA1、non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、TC/HDL-C差异具有统计学意义(P〈0.05,P〈0.01);non-HDL—C与TC、LDL—C、TG、HDL—C、apoA1、apoB100、apoB100/apoA1、TC/HDL均显著相关(相关系数0.4113—0.9893,P〈0.01)。结论非酒精性脂肪肝普遍具有代谢异常和肝脏受损特点,且性别之间表现不同,应采取针对性措施进行必要的预防和干预。
[ Objective] To compare the differences of biochemical metabolism between male and female nonalcoholic fatty liver patients and explore preventive countermeasures. [ Methods] Detection was made on the levels of TP, ALB, GLO, AST, ALT, TBIL, DBIL, IBIL, GLU, T CHO, TG, HDL C, LDL C, apoA1 and apoB 100 among 973 people who undertook physical examination; calculation was made on non HDL C and the ratio of apoB 100/apoA1, LDL C/HDL C, apoB 100/HDL C and TC/HDLC; comparison was made on the result between 59 nonalcoholic fatty liver patients and 202 healthy people in the control. [ Results] The total morbidity of fatty liver was 9.05% , the rate of the male patients was 12.53% , which was significantly higher than that of the female ones ( 6.0% ) ( P 〈 0.05 ) ; significant difference was found among the 59 male patients in the levels of ALT, IBIL, TG, HDL C, LDL C, apoA1, non HDL C and the ratio of apoB 100/apoA1, LDL C/HDL C, apoB 100/HDL C and TC/HDLC ( P 〈 0.05, P 〈 0.01 ) ; significant difference was also found among the 30 female patients in the levels of AST, TBIL, DBIL, IBIL, GLU, T CHO, TG, LDL C, apoA 1, non HDL C, and the ratios of apoB100/apoA1, LDL C/HD C, apoB 100/HDLC and TC/HDLC ( P 〈0.05, P 〈0.01 ) ; non HDL C was obviously correlated with TC, LDLC, TG, HDLC, apoA1, apoB100, apoB100/apoA1 and TC/FIDLC ( r =0. 4113 - 0. 9893, P 〈 0.01). [ Conclusion] Metabolism disorder and liver damage are the common features of nonalcoholic fatty liver and there are significant differences between males and females; effective measure should be taken for the prevention and interference.
出处
《职业与健康》
CAS
2007年第23期2135-2137,共3页
Occupation and Health
关键词
脂肪肝
性别
生化指标
Fatty liver
Sex
Biochemical marks