血管活性肠肽在中枢神经系统疾患作用的研究

The Effect of Vasoactive Intestinal Peptide on Central Nervous System Diseases

对30例急性脑炎脑病患儿的血浆和脑脊液(CSF)血管活性肠肽(VIP)含量进行了放免测定,并对其中11例CSF VIP进行了复查。结果表明,急性期血浆和脑脊液VIP水平均明显高于对照组(P<0.001),随着病情好转CSF VIP仍在较高水平维持2～3周。死亡患儿临终前CSFVIP水平多呈低值,提示VIP水平可作为病情严重程度的参考指标。

The levels of vasoactive intestinal peptide(VIP) in both plasma and cerebrospinal fluid were measured by radioimmunoassay in 30 children with acute encephalitis-encephalopathy , and 11 cases were serially reexamined. The results showed that the VIP levels in both plasma and cerebrospinal fluid were elevated in study group than in control group (P<0. 001). The high levels of VIP were usually kept for 2 - 3 weeks;but the levels were generally lower in the terminal stage. It was suggested that the VIP may be serve ask reference index of patient's condition.