妊娠期特发性脂肪肝8例临床分析

Clinical analysis of 8 cases of acute family liver during pregnancy

目的 探讨妊娠期特发性脂肪肝（AFLP）的临床特点,以便早期诊断和及时治疗。方法 对近7年我院收治的8例AFLP患者的临床资料进行回顾性分析。结果 所有患者白细胞及胆红素均升高。7例转氨酶升高,7例尿酸升高,6例纤维蛋白原降低,6例空腹血糖降低,5例白蛋白降低,5例血小板降低,凝血时间延长,5例尿素氨升高,4例血肌酐升高。孕产妇治愈7例,死亡1例,死亡率为12.5%。10例围生儿中,存活7例,死亡3例,死亡率为30.0%。结论 对高危人群行产前筛查可以降低AFLP发病率,早期诊断、及早终止妊娠和支持治疗是提高AFLP母儿预后的关键。

Objective To explore the clinical features of acute family liver of pregnancy（AFLP） for early diagnosis and management timely. Methods The clinical findings and outcome of pregnancy were analyzed in 8 patients with AFLP at our hospital in recent 7 years. Results WBC and bilirubin elevated in all patients. transaminase and uricacid elevated in 7 patients . Fibrinogen and blood fasting sugar decreased in 6 patients. Albumin decreased in 5 patients. Platelet decreased andclotting time prolonged in 5 patients. Urea nitrogen elevated in 5 patients. Serum creatinine elevated in 4 patients. 1 of 8 patients died, the mortality was 30%. Conclusion Pregnant women who are prone to suffer with AFLP, as well as their fetuses, should undergo antenatal screening of mother and children is to understand its characters, to make early diagnosis, and to termination of pregnancy timely.