特普他林对油酸肺损伤后肺水肿的抑制作用

Inhibitory effect of terbutaline on pulmonary edema in rats after acute lung injury induced by oleic acid

目的观察特普他林对油酸致伤大鼠肺损伤后肺水肿的影响。方法随机将大鼠分为正常对照组(C组)、油酸致伤组(I组)和特普他林治疗组(T组),T组于伤后1h经气管滴注特普他林(1×10-4M)溶液5ml/kg。分别于6、12、24h时相点检测总肺水量(TLW)、肺血管外肺水量(EVLW)和肺微血管通透性(PMVP),并同步检测动脉血气参数。结果油酸致伤后大鼠PMVP显著增高,TLW和EVLW明显增加,PaO2显著下降;特普他林治疗后,TLW、EVLW和PMVP均较油酸致伤组显著降低(P<0.01),低氧血症明显改善。结论特普他林明显降低油酸型肺损伤大鼠的肺微血管通透性和肺含水量,改善换气功能,对急性肺损伤后肺水肿有一定的治疗作用。

Objective To explore the inhibitory effect of terbutaline on pulmonary edema in rats after acute lung injury induced by oleic acid. Methods Rats were intravenously infused with oleic acid （0. 25 ml/kg） to establish pulmonary edema models and then were randomly divided into Control, Injured and Terbutaline groups. One hour later, terbutaline solution（10^-4 M, 5ml/kg） was instilled into trachea in terbutaline group. The pulmonary microvascular permeability（PMVP）, total lung water content （TLW）, extravascular lung water content（EVLW） and arterial blood gases were examined at 6, 12 and 24 hours respectively after infusion. Results The PMVP, TLW and EVLW were markedly increased, with ensuing severe hypoxemia. Compared with injured rats, terbutaline significantly decreased PMVP, TWL and EVLW, and improved hypoxemia. Conclusion Terbutaline can reduce edema accumulation and improve hypoxia in acute lung injury, and may have therapeutical effect on pulmonary edema after acute lung injury.