高血压患者凝血酶原及纤溶酶原激活物和其抑制物测定

Blood fibrinolysis activity of Healthy population and Hypertension

目的探讨正常人各年龄组间和高血压病人血纤溶指标的差异及其意义。方法用发色底物法分别时≤３９岁（ｎ＝４９），４０～５９岁（ｎ＝１４９），≥６０岁（ｎ＝６４）各组健康人和高血压组（ｎ＝５６）的血纤溶活性指标凝血酶原（ＰＬＧ），组织型纤溶酶原激活物（ｔ－ＰＡ）和纤溶酶原激活物抑制物（ＰＡＩ）进行测定。结果≥６０岁组和高血压组的ＰＬＧ和ｔ－ＰＡ明显低于５９岁以下各组（Ｐ＜０．００１），ＰＡＩ则明显高于５９岁以下各组（Ｐ＜０．００１）。结论健康老人（≥６０岁）和高血压病人纤溶活性降低。

Aim\ To investigate the blood fibrinolysis activity in hypertensive subjects.\ Methods\ Plasminogen(PLG),tissue type plasminogen activator(t PA),plasminogen activator inhibitor(PAI) were measured in healthy sujects in different normotensive age groups and compared with the hypertensive patients.\ Results\ PLG,t PA were decreased and PAI increased when age grow up.\ The PLG,t PA in hypertentive group was much lower than those in corresponding normotensive age groups( P <0 001), while PAI was much more increased( p <0 001).\ Conclusion\ Blood fibrinolysis activity were decreased in health elderly(≥60) with age and in hypertensive patients.