硝苯地平对高血压患者脑循环血流动力学的影响

Effect of Nifedipine on Hemodynamics of Cerebral Circulation in Patients with Essential Hypertension

目的研究硝苯地平对高血压病人脑循环血流动力学的影响。方法利用脑血管功能检测仪对４５例原发性高血压患者含服硝苯地平前后的血流动力学指标进行检测并分析了指标变化与血压下降间的关系。结果硝苯地平可以增加Ⅰ、Ⅱ期病人颈总动脉血流速度，降低脑血管外周阻力、特性阻抗及脉搏波速度；Ⅰ期各项指标的改善与血压变化无关，Ⅱ、Ⅲ期外周阻力的变化与血压变化有相关性。结论硝苯地平可以改善Ⅰ、Ⅱ期原发性高血压患者的脑循环血流动力学指标，其中直接扩张脑血管可能比降低血压起着更为重要的作用。

Aim\ To investigate the effect of nifedipine on cerebral circulation in patients with essential hypertension.\ Methods\ The patients' cerebrovascular dynamics indexes(CVDIs) were investigated before and after receiving 10 mg of sublingual nifedipine. The relationships between the alterations of CVDIs and that of blood pressure were studied.\ Results\ The CVDIs were improved significantly in stage Ⅰ,Ⅱ patients but not in stage Ⅲ patients;significant correlation coefficients were only found between alterations of cerebrovascular resistance(R) and that of blood pressure in stage Ⅱ, Ⅲ patients.\ Conclusion\ Nifedipine can improve CVDIs of esssential hypertensive patients, especially in stage Ⅰ, Ⅱ. It may be ascribed not only by autoregulative mechanism caused by decreased blood pressure,but also more important by directly dilating the cerebral arteries.