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肿瘤基因组中体细胞性改变的研究进展

Progress in research on somatic alterations in the oncogenome
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摘要 大部分人类肿瘤是由基因组中的体细胞性改变所导致的癌基因激活或抑癌基因失活所引发的.本文总结了近年来肿瘤基因组中体细胞性改变的研究状况,我们主要关注人类基因组计划为肿瘤相关基因的鉴定所带来的机遇并讨论以全基因组分析为基础的研究进展. Somatic alterations within the oncogenome underlie the genesis and progression of most human tumors, by causing oncogene activation or tumor suppressor gene inactivation. The present review summarizes our current knowledge of these areas and the progress that has been made. The purposes of this review are to highlight the importance of the human genome project to identify cancer genome alterations, and to discuss the advancement of research on systematic cancer genome analysis.
作者 杨壹羚 褚嘉祐
机构地区 中国医学科学院北京协和医学院医学生物学研究所遗传室
出处 《世界华人消化杂志》 CAS 北大核心 2007年第28期3029-3034,共6页 World Chinese Journal of Digestology
基金 美国中华医学基金会(CMB)资助项目 No.04-805~~
关键词 肿瘤基因组 体细胞性改变 人类基因组计划 突变 Oncogenome Somatic alterations Hu-man genome project Mutation
分类号 R730.43 [医药卫生—肿瘤]
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参考文献46

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世界华人消化杂志
2007年 第28期

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