益肾胶囊对慢性肾小球肾炎患者血清血管内皮生长因子及细胞免疫的影响

Effect of Yishen capsule on serum vascular endothelial growth factor and cell immunity in patients with chronic glomerulonephritis

目的:探讨益肾胶囊对慢性肾小球肾炎患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)和细胞免疫的影响及疗效。方法:检测了30例健康查体者和83例患者治疗前后VEGF和T淋巴细胞亚群的改变。结果:慢性肾炎患者治疗前CD3,CD4,CD4/CD8降低,CD8和血清VEGF水平明显增高(P<0.05或P<0.01)。经过3个月的治疗其CD8和血清VEGF水平明显降低,CD4/CD8比例上升(P<0.05或P<0.01);其总有效率为90.4%。结论:益肾胶囊具有降低慢性肾小球肾炎患者尿蛋白、提高患者免疫功能,改善临床症状,从而起到延缓慢性肾小球硬化进程的作用。

Objective： To explore the effect of Yishen capsule on the serum vascular endothelial growth factor （VEGF） , the cell immunity and the theraphic. Method： Serum VEGF and T cell subsets were studied in 30 normal subjects and 83 patients before and after treatment. Result： Compare with normal subjects, CD3, CD4, CD4/CD8 were decreased, CD8 and serum VEGF were increased obviously （ P 〈 0. 05 or P 〈 0. 01 ）. After three months treatment with YiShen capsule, CD4/CD8 was increased, CD8 and serum VEGF were decreased significantly （P 〈 0.05 or P 〈 0. 01 ）. Conclusion： Yishen capsule can reduce the pmteinuria, increase the function of immunity and improve the clinical symptom of patients with chronic glomerulonephritis, achieved the effects of allevating chronic glomerular sclerosis ultimately.