盐酸曲唑酮联合西地那非治疗早泄的疗效观察

Clinical efficacy of trazodone hydrochloride with sildenafil against premature ejaculation

目的:探讨盐酸曲唑酮联合西地那非并配合心理行为治疗早泄的临床疗效。方法:68例早泄患者随机均分为实验组(盐酸曲唑酮加西地那非加行为疗法)和对照组(盐酸曲唑酮加行为疗法),记录治疗前后阴道内射精潜伏期并进行组内和组间比较,同时记录夫妻对性生活的满意情况。结果:治疗前,实验组和对照组阴道内射精潜伏期分别为(0.79±0.34)min、(0.85±0.38)min,治疗后分别为(4.32±2.30)min、(2.84±1.45)min,差异有统计学意义(P<0.01),且实验组阴道内射精潜伏期较对照组相比差异有统计学意义(P<0.01)。夫妻双方对性生活的情况:满意率实验组(64.5%)明显高于对照组(35.3%),差异有统计学意义(P<0.05),而总满意率(满意加基本满意)实验组(84.6%)亦高于对照组(70.6%),但差异无统计学意义(P>0.05)。结论:盐酸曲唑酮联合西地那非并配合心理行为疗法在延长射精潜伏期,改善夫妻双方性生活满意度方面明显优于盐酸曲唑酮配合心理行为疗法,两药合用在治疗早泄方面有一定的应用前景。

Objective：To study the clinical efficacy of trazodone hydrochloride plus sildenafil combined psychotherapy and physical training against premature ejaculation（PE）. Methods：Sixty-eight PE patients were divided into two groups randomly： experimental gro r） （trazodone hydrochloride plus sildenafil combined behavior therapy） and control group（trazodone hydrochloriae combined behavior therapy）, Intra-vaginal ejaculation latency time （IELT） and the coitus satisfaction of patient and the partner were recorded before and after treatment. Results： The IELTs of two groups were （0.79±0.34） and （0.85±0.38） minutes respectivety before treatment, （4.32±2. 30） and （2.84± 1.45） minutes after treatment, there was significant difference between before treatment and after treatment （P〈0.01）; there was significant difference between experimental group and control group（P〈 0.01）. As sex satisfaction degree, satisfaction rate produced better results in experimental group（64.5%）than control group（35.3 %）, there was significant difference （P〈0.05）, total satisfaction rate（satisfaction＋ basic satisfaction） produced better results in experimental group （ 84.6 % ） than control group （ 70.6 % ）, but there was no significant difference （P〉0.05）. Conclusions： As for IELT and sex satisfaction degree, trazodone hydrochloride plus sildenafil combined behavior therapy produced better results than trazodone hydrochloride combined behavior therapy, which suggests that combined therapy may be helpful against premature ejaculation.