新生儿早期细菌感染与围产期高危因素的相关性研究

The correlation between early onset of neonatal bacterial infection and perinatal risk factors

目的探讨新生儿早期细菌感染与围产期高危因素的相关性。方法随机选择本院新生儿监护室中符合纳入标准的,日龄≤72h的具有围产期高危因素的新生儿120例。按患儿临床表现及实验室辅助检查分为确定感染组、临床感染组及非感染组,以统计学方法分析7项围产因素与新生儿早期细菌感染之间的关系。结果(1)与新生儿早期细菌感染显著相关的围产期高危因素依次为:母亲妊娠期感染;不明原因窒息;不明原因早产;羊水粪污染(P<0.05),且两感染组间比较,差异无统计学意义(P>0.05)。(2)母亲分娩时发热(体温≥38℃);胎膜早破≥18h;糖尿病母亲婴儿这3项围产期高危因素未发现与新生儿早期细菌感染显著相关(P>0.05)。结论新生儿早期细菌感染的发生与几项围产期高危因素密切相关,其中母亲妊娠期感染是最高危的因素,其在两感染组的OR值分别为83.333和66.666。

Objective To study the correlation between early onset of neonatal bacterial infection and the perinatal risk factors. Methods One hundred twenty infants born within 72 hours were randomly selected from the NICU of The First Affiliated Hospital of Kuming Medical College that they had predispo- sing high risk perinatal factors. The infants were assigned allocated into confirmed infection group, clinical infection group and non-infection group according to their clinical presentations and laboratory test results. The correlation between early onset of neonatal bacterial infection and seven perinatal risk factors was analyzed statistically. Results The risk factors of early onset of neonatal bacterial infection were correlated significantly （ P 〈 0. 05 ） with the following factors, in order from high to low, mothers with confirmed infection （s） during pregnancy, neonatal asphyxia with unknown etiologies, premature labor with unknown etiologies and meconium stained amniotic fluid. There was no significant difference （P 〉 0. 05 ） between groups of confirmed infection and clinical infection. This study did not show any statistical significance （ P 〉 0. 05） between early onset of neonatal bacterial infection and maternal fever （ temperature≥38℃） during delivery, prolonged rupture of membrane （PROM）≥ 18 h and maternal diabetes. Conclusions The incidence of early onset of neonatal bacterial infection is closely related to perinatal risk factors, among which confirmed maternal infection （s） during pregnancy is the highest and its Odds Ratio （OR） are 83. 333 and 66. 666 in confirmed infection group and in clinical infection group.