西地那非抗ED治疗的临床研究

An update on the clinical application of sildenafil for erectile dysfunction

西地那非(Sil)作为第一个口服抗勃起障碍(ED)药物问世以来,从基础到临床进行了广泛的研究,成果丰硕。循证医学资料表明,Sil治疗ED具有良好的安全性、耐受性,有效率达80%以上,对不同病因和多种伴发疾病以及并用除硝酸类外药物的ED患者均有显著疗效。本文还对Sil长期服用的可行性进行了评述。

Since sildenafil （Sil） was marketed as the first oral drug for the treatment for erectile dysfunction（ ED）, much achivements were available from in vitro experiments and clinical trials. Clinical data from evidence -based medicine have confirmed that its use for ED was safe, tolerable and effective （ effective rate ： 〉 80% ）, irrespective of varying etiologies and diverse comorbidities, or receiving concurrent combinations of other drugs but nitraties. In this review the feasibility of long - term use of Sil for ED is also discussed.