男性人乳头瘤病毒感染与生殖器癌的相关性

Analyses of Human Papillomavirus Infection and Anogenital Cancer in Men

生殖器人乳头瘤病毒(HPV)感染是全球最常见的性传播性疾病(STD)之一,与癌症、生殖器疣和其他上皮损害相关。在过去20年中关于女性生殖器HPV感染的流行病学和发病机制已经有了较多研究,而对于这些感染在男性是如何发生发展却了解甚少。随着HPV疫苗的发展,更需要了解男性HPV感染的发病和发展,从而可以通过更有效的方法如免疫接种和促进高危因素下降等策略来预防此病。

Objective Genital human papillomavirus （HPV） infection,one of the most common sexually transmitted infec- tions,is associated with cancers, genital warts, and other epithelial lesions. Although a consistent and coherent picture of the epide- miology and pathogenesis of genital HPV infections in women has developed over the past two decades, less is known about these infections in men. With the anticipated availability of prophylactic HPV vaccines in the near future,it becomes increasingly impor- tant to understand the incidence and duration of HPV infections in men to develop more effective approaches to prevention through a combination of immunisation and promotion of risk-reduction strategies.