复方地黄酊湿敷治疗化疗性静脉炎的实验研究

An experimental study on wet compress with compound Dihuang tincture to treat chemotherapeutic phlebitis

[目的]探讨复方地黄酊湿敷对化疗药物所致家兔耳缘静脉炎的疗效。[方法]将36只成年家兔随机分为A组(空白对照组)、B组(应用复方地黄酊湿敷组)、C组(50%硫酸镁湿敷组),分别在家兔耳缘静脉注射盐酸多柔比星造成静脉炎模型,各采用不同治疗方法分别在治疗后2h、4h、6h、24h,用肉眼和组织病理学两种方法观察血管周围出血及水肿、炎性细胞浸润、血栓形成、血管壁增厚方面的变化。[结果]治疗后2h、4h、6h,B组、C组在炎细胞浸润、血栓形成、血管周围出血、血管周围水肿方面与A组比较,差异均有统计学意义(P<0.05);治疗24h,B组、C组差异具有统计学意义(P<0.05)。[结论]复方地黄酊湿敷可减轻化疗性静脉炎引起的局部组织损害,促进局部损伤组织修复,效果优于50%硫酸镁湿敷。

Objective： To probe into the curative effect of wet compress with compound Dihuang tincture to treat phlebitis of ear - edge vein of rabbit caused by chemotherapeutic drugs. Methods： A total of 36 adult rabbits were divided into group A （blank control group）, B （wet compress with compound Dihuang tincture） and C （50% magnesium sulfate ）. Then phlebitis models were prepared by injecting doxombicin hydrochloride in ear-edge vein of rabbit. The changes of hemorrhage and edema around vessels, inflammatory cells infiltration, thrombosis and thickening of capillary walls were observed with naked eye and histopathologically at 2 h, 4 h, 6 h, and 24 h respectively after injection. Results： There were statistical significant differences in terms of hemorrhage and edema around vessels, inflammatory cells infiltration and thrombosis between group B, C and group A at 2 h, 4 h, 6 h after injection （P〈0.05）. And there were statistical significant differences between group B and C at 24 h after treatment （P 〈 0.05）. Conclusion： Wet compress with compound Dihuang tincture can abate local histological lesion of chemotherapy induced phlebitis and promote the repair of local damaged tissues. The effect of wet compress with compound Dihuang tincture is better than applying 50 % magnesium sulfate.