分子印迹聚合物微球的制备及表征技术

Progress of Preparation and Characteristics of Molecularly Imprinted Polymeric Microspheres

分子印迹聚合物微球作为一种具有分子识别能力的新型高分子材料,以其吸附选择性好、色谱效率高、便于功能设计等优点在固相萃取、药物手性分离等领域取得了应用。本文介绍了分子印迹聚合物微球的主要制备方法,比较了不同的聚合物微球制备方法用于分子印迹技术中的特点,同时针对不同聚合方法对分子印迹聚合物微球性能的影响作了相应评述,此外对其结构与性能的表征方法也作了较为详细的介绍,在此基础上分析了存在的问题及今后的发展方向。

As a new polymer material, molecularly imprinted polymeric microspheres （MIPMs） have attracted great interest for peculiar molecular recognition. MIPMs have a series of advantages, such as excellent selectivity, high adsorption, high efficiency in chromatography and easy design. MIPMIS can be used in some high technology fields, for instance solid-phase microextraction and chiral separations of pharmaceutical etc. In this article, the main methods of preparation of MIPMs were introduced, the advantages and disadvantages of these methods were also summarized. The effects of the methods on the properties＇ of MIPMs were discussed. The characteristics methods of structure and performance were also introduced in detail. On the base of these reviews, the problems need to be resolved and the trends of development were discussed.