手部嗜中性皮病

Neutrophilic dermatosis of the dorsal hands:report of three cases

报告3例手部嗜中性皮病。3例患者均为女性,有相似的临床和组织病理学特点,无发热、关节痛等全身症状。2例患者组织病理上有明显的血管炎改变。3例患者均未并发骨髓增生不良性疾病、髓细胞性白血病和炎症性肠病;对口服泼尼松、雷公藤多苷和5%碘化钾均有明显疗效。3例患者的临床表现、组织病理学改变以及对糖皮质激素等治疗的反应均支持手部嗜中性皮病是一种局限型的Sweet综合征。

Three cases of neutrophilic dermatosis of the dorsal hands were reported. All patients had similar clinical and histologic features. No systemic manifestations such as fever, arthralgia, or generalized malaise accompanied them. Two patients had distinct histologic evidence of vasculitis. None patient associated with myeloproliferative disorders, myelocytic leukemia and inflammatory bowel disease. All 3 patients highly responded to systemic corticosteroid, Triperygium wilfordii and 5% potassium iodide. The clinical appearance, histologic features, and response to corticosteroid of the 3 patients provide strong evidence that neutrophilic dermatosis of the dorsal hands is a localized variant of Sweet syndrome.