患者服FK506的剂量、血药浓度、服药天数的三维图像解析

Analysis of 3-dimensions images of the dose period of Prograf,dosage and concentration within kidney transplantation recipients

研究分析老、中、青年肾移植患者服用普乐可复剂量、血药浓度、服药天数的三维图像,使患者临床用药形象化显现,为个体用药提供信息。将60岁以上老年患者、40-59岁中年患者与小于40岁青年患者分三组,采用MATLAB7.0做三维图像,分析图像特征并且对老年、中年、青年组图像进行比较。三维图像显示出各项指标间存在内在关系与个体差异。体内指标与服药天数相关,体内指标对临床个体用药具有重要意义。

To investigate the correlation of dose period of prograf （FK506）, FK506 dosage, and concentration of elder, middle age and youth kidney transplantation recipients, providing individual information to clinical. Those items were divided into three groups and were disposed by MATLAB 7. 0 software according to elder, middle age and youth age. Those were anatomized that the character of images, different situation that taking medicine and items in vivo in recipients. 3 - Dimensions images showed indicators in vivo having internal correlation and individual difference. The administration period of FK506 after kidney transplantation can influence indicator in vivo in middle age and youth recipients. These indicators give a reference to individual clinical administration.