肝癌伴脾功能亢进的双介入治疗

Embolization of both hepatic and splenic arteries in primary hepatic carcinoma associated with hypersplenism

目的评价联合应用肝动脉灌注化疗栓塞和部分性脾栓塞治疗肝癌伴脾功能亢进的临床价值及意义。方法收集肝癌伴脾亢58例,经导管肝动脉栓塞(TACE)同时行部分性脾栓塞(PSE),观察术前术后血细胞变化情况。结果TACE联合PSE治疗肝癌合并脾亢可明显改善患者外周血象,术后24小时、1周、2周及4周外周血白细胞、红细胞及血小板较栓塞前明显提高。结论对于肝癌合并脾功能亢进患者,在行肝动脉栓塞灌注化疗同时行部分性脾栓塞术,安全可靠,既能有效控制肿瘤发展,又能有效改善患者血象,提高机体免疫力和患者的生活质量。

Objective To evalute the clinical efficiency and significance of partial splenic embolization and transcatheter arterial chemoembolization in patients who have primary hepatic carcinoma associated with hypersplenism. Methods Fiftyeight patients of primary hepatic carcinoma associated with hypersplenism were treated by transcatheter arterial chemoembolization and partial splenic embolization, observing all patients the change of blood count before and after the operation. Results To obviously improve the blood count of all patients by transcatheter arterial chemoembolization and partial splenic embolization,such as WBC, RBC and PLT were increased after the 24 hours and several weeks. Conclusion Transeatheter arterial chemoembolization and partial splenic embolization are safe and effective treatment techniques in patients with primary hepatic carcinoma associated with hypersplenism, they have the effect controlling development of primary hepatic carcinoma, increasing blood cell counts, elevating immunity and improving living quality.