摘要
通过培养的免主动脉血管平滑肌细胞（ＶＳＭＣ）氚胸腺嘧啶核苷掺入量和培养液中超氧化物歧化酶（ＳＯＤ）、脂质过氧化物、前列环素（ＰＧＩ２）及环磷酸腺苷（ｃＡＭＰ）的测定，观察了当归注射液对ＶＳＭＣ增殖的影响。结果表明：当归注射液有抑制ＶＳＭＣ增殖的作用，其作用呈剂量依赖关系。当归注射液可能通过增加ＳＯＤ活性，降低脂质过氧化物水平，升高ＰＧＩ２、ｃＡＭＰ水平（Ｐ均＜０．０５），从而抑制ＶＳＭＣ增殖。
The effects of angelica injection on the proliferation of cultured rabbit aortic smooth muscle cells (SMC) were studied with 3 H thymidine ( 3H TdR) incorporation data of SMC and contents of superoxide dismutase(SOD), lipid peroxide (LPO), prostacyclin (PGI 2) and cyclic AMP (cAMP) in medium. The results showed that angelica injection may inhibit SMC proliferation by increasing SOD activity, decreasing LPO, raising PGI 2 and cAMP (all P <0.05),and the inhibitory action accompanied with the dose effect relation.
关键词
当归注射液
主动脉
平滑肌
细胞增殖
药理
plant extracts/PD
cells, cultured
muscle, smooth, vascular
thymidine
