摘要
１９８７年５月至１９９３年５月，我科共收治２４例首次手术未达最佳缩瘤（残瘤＞２ｃｍ）要求的晚期上皮性卵巢癌患者，其中１４例给予化疗２～３疗程后进行了间歇性２次缩瘤术，均达最佳缩瘤之要求，术后残余瘤直径≤２ｃｍ，平均生存时间２２．５６月。未行２次缩瘤术的１０例病人接受联合化疗，平均生存时间为１３．４０月，两者比较差异有显著性（Ｐ＜０．０５）。认为化疗次数是影响预后的因素（Ｐ＜０．０１），而病理类型、病理分级、年龄对生存时间无明显影响。
Twenty four patients of advanced epithelial ovarian cancer who had >2 cm residual disease after initial surgery from May 1987 to May 1993 were treated in our department of oncology. 14/24 patients received further surgical debulking (interval debulking surgery) after two to three cycles of chemotherapy. Optimal cytoredution to ≤2 cm was achieved for all the patients. The remainder 10 patients only received combined chemotherapy. The survival of patients who underwent interval debulking was significantly better than that of those who did not (p<0.05). The number of cycles of chemotherapy was a significant prognostic factor for survival (p<0.01). There was no relationship between the survival and histologic grade and patients age. The result shows that interval debulking may improve quality of life and prolong survival time for advanced ovarian carcinoma
关键词
卵巢肿瘤
外科手术
ovarian neoplasms/SU
methods
