北京地区发生庚型肝炎病毒感染的初步研究

PRELIMINARY INVESTIGATION OF GBV C INFECTION IN BEIJING DISTRICT

庚型肝炎病毒（ＧＢＶ－Ｃ／ＨＧＶ）是最近被证实的一种致人类肝炎病毒，用ＲＴ－ＰＣＲ法以ＧＢＶ－Ｃ的５′端非编码区的序列为引物，对北京地区４１例非Ａ～Ｅ病毒性肝炎患者检测，发现有２６．８％的ＧＢＶ－Ｃ感染者。他们的临床表现为：ＡＬＴ反复低水平异常，具有轻型慢性肝炎的表现。值得注意的是，虽然ＧＢＶ－Ｃ可通过血液传播，但本组大部分ＧＢＶ－Ｃ患者无输血史。说地区较高的ＧＢＶ－Ｃ感染率值得重视。

It is now generally believed that the two recently identified human hepatitis virus GBV C and HGV were the same because 85 5% nucleotide identity and 100% amino acid identity were found in their genome. Using the RT PCR method with the primers from the sequence of 5′ non coding region of GBV C we investigated 41 patients of non A through E (non A E) in Bejing District. It was identified that 11 cases(26 8%) of these patients were of GBV C infection. The clinical characteristics of GBV C infection were fluctuation of low grade elevation of ALT and mild chronic hepatitis. It is noticeable, although GBV C is transmissable through blood transfusion, but just like HCV, the majority of the HGV patients had no history of transfusion. High rate of infection of GBV C in this District was emphasized.