胃癌组织内淋巴管的形态计量学研究

Morphological quantitative analysis of lymphatic vessels in human gastric carcinoma

目的：研究胃癌细胞淋巴道转移机理。方法：用图像分析仪测定３２例胃癌组织及癌旁组织内有腔淋巴管和毛细淋巴管最大面积、周径和管径。结果：在胃癌组织内以条索状毛细淋巴管为多，而在癌旁组织内则以开放的淋巴管和毛细淋巴管为主；图像分析结果表明：转移组胃癌组织与癌旁组织内淋巴管和毛细淋巴管腔面积、周径和管径，两者间彼此差异均有显著性（Ｐ＜０．０５）；未转移组胃癌组织与癌旁组织内淋巴管和毛细淋巴管腔面积、周径和管径两者间差异亦有显著性（Ｐ＜０．０５）；比较转移组与未转移组癌旁组织内淋巴管毛细淋巴管最大腔面积、周径和管径，彼此差异亦有显著性（Ｐ＜０．０５）。结论：结果提示胃癌旁组织间质水肿导致淋巴管和毛细淋巴管扩张，有助于癌细胞的转移，癌细胞转移是通过浸润癌成熟的毛细淋巴管转移到淋巴结的。

Purpose To study the mechanism of lymphous metastasis of gastric carcinoma. Methods Morphological changes of lymphatic vessels and capillaries in 32 cases of gastric carcinoma and peritumoral tissues were studied with image analysis technique. Results There were a lot of lymphatic vessels and capillaries with opened lumen in peritumoral tissues and line like lymphatic capillaries in gastric carcinoma. The significantly statistical differences in the maximal lumen area, perimeter and diameter of lymphatic vessels and capillaries were obsered between the gastric carcinoma tissues and their peritumoral tissues in the metastatic group ( P< 0 05), and the non metastatic group ( P< 0 05) as well as between the peritumoral tissuse in the metastatic group and those in the non metastatic group ( P< 0 05). Conclusions These results suggest that dilation of lymphatic vessels and capillaries due to edema within or in peritumoral connective tissues favour the metastasis of human gastric carcinoma cells and that lymphous metastasis of carcinoma cells occour through mature lymphatic capillaries in peritumoral tissues.