鼻腔和鼻咽非霍奇金淋巴瘤EB病毒潜伏膜蛋白表达

Expression of Epstein Barr virus latent membrane protein 1 and its significance in nasal and nasopharyngeal lymphoma

目的：探讨鼻咽癌高发区人群鼻咽／鼻腔原发非霍奇金淋巴瘤（ＮＨＬ）与ＥＢ病毒（ＥＢＶ）感染的关系。方法：对４１例鼻咽和鼻腔ＮＨＬ进行免疫细胞学分型以及ＥＢＶ潜伏膜蛋白（ＬＭＰ１）检测。结果：发现：①鼻咽／鼻腔ＮＨＬ的ＬＭＰ１检出率为４８．８％（２０／４１）；②鼻咽ＮＨＬ的ＬＭＰ１检出率３７．９％（１１／２９），鼻腔７５％（９／１２）；③Ｔ细胞性淋巴瘤ＬＭＰ１检出率６０％（１５／２５），Ｂ细胞性淋巴瘤３１．３％（５／１６）。结论：上述研究结果提示，本地区鼻咽／鼻腔ＮＨＬ与ＥＢＶ感染有较密切的关系，其中又以鼻腔ＮＨＬ和Ｔ细胞性淋巴瘤关系更为密切。

Purpose To research the relation between EBV infection and non Hodgkins lymphoma. Methods Forty one cases with primary nasal and nasopharyngeal non Hodgkins lymphoma (NHL) from a high incidence area of nasopharyngeal carcinoma were studied on presence of LMP 1, using immunohistochemical technique. Results Of the 41 cases, 20 (48 8%) showed expression of LMP 1. The expression of LMP 1 in nasal NHL was higher than that in nasopharyngeal, 9 of 12 (75%) and 11 of 29 (37 9%) respectively. 25 of 41 (61%) were CD 45RO positive (T lymphoma) and 16 of 41 (39%) CD 20 positive (B lymphoma). The positivity rate of LMP 1 in T lymphoma was 15/25 (60%), in B lymphoma 5/16(31 3%). Conclusions The findings suggest that there is a close relationship between EBV infection and nasal/nasopharyngeal NHL, especially nasal NHL and T lymphoma.