兔胃、肝血管TH胶栓塞后周围组织的病理学改变

Pathological changes of peri vascular tissues after gastric and hepatic vascular embolization with medical TH tissue adhesive in rabbits

目的：了解ＴＨ胶栓塞血管后引起的周围组织的病理改变。方法：在对兔胃、肝静脉栓塞后，分别于２４ｈ、４８ｈ、７２ｈ、１周、２周处死。对动物标本进行肉眼和光镜观察。结果：血管栓塞后局部血流停滞、淤血、缺氧，周围组织发生无菌性坏死及炎症。肝细胞变性坏死，肝内纤维组织及肝细胞的结节性增生。胃粘膜出血、坏死、脱落形成溃疡。但这些损害较为局限，多可自行愈合。结论：提示在血管内栓塞治疗中，应严格掌握ＴＨ胶用量，控制栓塞范围及防止异位栓塞。

Purpose To investigate the pathological changes of peri vascular tissues on rabbit following vascular embolization with medical TH tissue adhesive. Methods Rabbits were killed and their samples were observed by light microscopy at 24、48、72 hours, 1 week and 2 weeks respectively after embolization of gastric and hepatic veins. Results Non bacterial necrosis and inflammation was found in peri vascular tissues. The tissue injury was induced by local blood flow stopping and hypoxia. The liver manifested hepatocyte degeneration, necrocytosis and proliferation of fibrous tissues and hepatocytes proliferated tubercularly finally. The gastric ulcer was induced by mucosal necrosis. But these injuries were local and self recoverable. Conclusions It is suggest that the dosage of TH tissue adhesive and embolized area should be controlled and that embolization in unexpected areas should be avoided.