沙棘总黄酮对急性心衰犬心功能和血流动力学的影响

Effects of Total Flavones of Fructus Hippophae(TFH) on Cardiac Function and Hemodynamics of Anesthetized Open chest Dogs with Acute Heart Failure

以戊巴比妥钠造成麻醉开胸犬心衰模型，ｉｖ沙棘总黄酮（ＴＦＨ）４８，９７ｍｇ／ｋｇ，均可使心衰犬ＣＯ，ＣＩ，＋ＬＶｄＰ／ｄｔｍａｘ和ＬＶＳＰ明显升高，ＴＦＨ９７ｍｇ／ｋｇ时ＲｄＰ／ｄｔｍａｘ明显缩短；－ＬＶｄＰ／ｄｔｍａｘ明显增加，Ｔ值、ＬＶＥＤＰ明显下降；ＴＰＶＲ和ＭＶＯ２Ｉ明显降低，ＭＡＰ和ＨＲ无明显影响。结果提示，ｉｖＴＦＨ可明显增强心衰犬心脏泵功能和心肌收缩性能，并可明显改善心肌舒张性能，降低外周血管阻力和心肌耗氧量。

This study was carried out employing the model of dog with acute heart failure induced by phenobarbital natricum. It was shown that iv TFH 4.8 and 9.7mg/kg could significantly increase CO,CI,+LVdP/dtmax and LVSP;shorten R dP/dtmax in 9.7mg/kg;raise-LVdP/dtmax,reduce LVEDP and T value ;decrease MVO 2I and TPVR;MAP and HR were not changed significantly. The results suggest that iv TFH can strengthen cardiac pump function and myocardial contractility in canine with heart failure; significantly improve myocardial diastolic function and hemodynamic performance;markedly decrease myocardia used oxygen index and total peripheral vessel resistance, thus proving that TFH is good for heart failure.