摘要
目的研究薯蓣皂苷元(MPD)对犬心脏血流动力学的影响,阐明其对心血管系统的作用。方法观测MPD对正常麻醉犬动脉血压、冠脉流量、冠脉阻力和总外周阻力、左室做功等血流动力学参数的影响。结果MPD可扩张冠脉血管及外周血管,增加冠脉流量,降低冠脉阻力;改善左室做功和心肌氧利用率,调整心脏血管的顺应性。结论MPD对犬心脏血流动力学起到调整和改善作用。
Objective To investigate the pharmacological effects of MPD on heart hemodynamics and myocardial oxygen consumption in dogs, and to study its mechanism. Methods The changes of parameters such as blood pressure （BP）, coronary blood flow, myocardial oxygen consumption and heart rates were observed in normal anesthetic dogs. Results Compared to those in the normal group, MPD can obviously lower the BP and peripheral vascular resistance, dilate the coronary and peripheral artery, increase the coronary blood flow and improve the left ventricle function and myocardium oxygen consumption rate. Conclusion MPI） can improve the heart hemodynamics and regulate myocardium oxygen consumption.
出处
《中药新药与临床药理》
CAS
CSCD
2007年第6期421-424,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金面上项目(C03050205)
关键词
薯蓣皂苷元
血流动力学
总外周阻力
Methy protodioscin
Hemodynamics
Peripheral vascular resistance
