山茱萸炮制前后多糖成分对肾阴虚模型小鼠的抗衰老作用

Anti-aging Effect of Polysaccharides from Crude and Processed Cornus Officinalis on Mice with Deficiency of Kidney

目的探讨山茱萸炮制前后多糖成分对肾阴虚模型小鼠抗衰老作用的差异。方法通过灌胃给药,观察山茱萸炮制前后粗多糖对肾阴虚模型小鼠负重游泳时间、耐缺氧时间、血清SOD活性、MDA含量的影响。结果山茱萸制品多糖较生品更能显著延长肾阴虚小鼠负重游泳时间、耐缺氧时间,提高SOD活性,并降低MDA含量。结论山茱萸多糖对肾阴虚模型小鼠有一定的抗衰老作用,且制品作用优于生品。

Objective To compare the anti - aging effect of polysaccharides from crude and processed Cornus Officinalis on the mice with deficiency of kidney. Methods The mice were given the drugs by gastric perfusion. The effect of polysaccharides on the time of weight- loading swimming, anti- hypoxia time , and serum SOD activity and MDA content in mice with kidney deficiency was observed. Results Compared to the crude Cornus Officinalis, the polysaccharides from the processed product can markedly prolong the time of weight - loading swimming, anti - hypoxia time, promote the activity of SOD and decrease the content of MDA. Conclusions Polysaccharides from Cornus Officinalis have certain anti - aging effect on the mice with deficiency of kidney, and the effect of the processed is superior to that of the crude.