虫草多糖对腺嘌呤诱发慢性肾衰大鼠的治疗作用

Therapeutic Effects of Cordyceps Polysaccharide on Adenine-induced Chronic Renal Failure in Rats

目的探讨虫草多糖对腺嘌呤诱发的慢性肾功能衰竭大鼠的治疗作用。方法采用腺嘌呤灌胃复制大鼠慢性肾衰(CRF)模型,将大鼠随机分为正常组,模型组,虫草多糖高、中、低剂量组和地塞米松组,观察治疗后大鼠的肾功能、血液生化指标、肾病理、肾脏指数及血清TNF-α的变化。结果虫草多糖各组肾功能受损程度明显轻于模型组,肾脏病理损伤明显减轻,血清TNF-α的含量明显减少,肾脏脂数明显下降。结论虫草多糖能够防治腺嘌呤诱发的慢性肾功能衰竭,有效预防慢性肾衰的发生、发展,改善肾功能。

Objective To study the therapeutic effects of Cordyceps polysacchafide （CP） on adenineinduced chronic renal failure（CRF）in rats. Methods CRF model was induced by Adenine ig . The rats were randomized into normal group, model group, CP high, moderate, Low - dosage groups and Dexamethasone group. The models of adenine - induced nephrosis were established by intragastric administration of adenine 300 mg/kg for 21 days. After treatment, renal function, biochemical indicators, kidney index, renal pathologic changes and serum TNF - α were observed. Restilts Compared with the model group, the degree injury of renal function in CP groups was palliated significant, renal pathologic changes were palliated significant, renal index and content of serum TNF - α were both decreased significant. Conclusion CP has a therapeutic and preventive effect on adenine - induced CRF, and can prevent the generation and development of CRF, improve renal function.