普瑞博思治疗慢性消化不良的临床疗效观察

An investigation of efficacy of cisapride on chronic dyspepsia

本文观察普瑞博思对慢性消化不良的治疗效果。选择曾用胃复安或吗叮啉治疗2～4周无效的慢性消化不良病人173例；随机分为两组：普瑞博恩组91例，服用普瑞博恩5mg，每日3次；雷尼替丁组82例，服用雷尼替丁150mg，每日2次。两组疗程均为4周。分别观察第2及第4周消化道症状变化及不良反应。结果表明，普瑞博恩组总有效率95．6％，出现不良反应占16．5％，多数能耐受。雷尼替丁组总有效率43．9％，两组总有效率相比具有非常显著差异（P＜0．001）。提示：普瑞博思对用胃复安或吗叮啉治疗无效的慢性消化不良有显著疗效，是一种安全而有效的胃肠道促动力药。

This study was undertaken to investigate the efficacy of cisapride on chronic dyspepsia. 173 patients with dyspepsia and without response to the treat-ment of metoclopramide and domeridone for two to four weeks were randomly di-vided into two treatment groups. Cisapride group: cisapride 5mg t. i. d for four weeks. Control group: ranitidine 150mg b- i, d for four weeks. Total effective rate was 95. 6% in cisapride group, whereas 43. 9% in contro1 group. There was a very significant difference between their efficacies (P<0. 001). The efficacy of cisapride was related to the clinica1 type of dyspepsia, whereas no related to age, sex, and duration of dyspepsia. The incidence of side effect in cisapride group was 16. 5%.Most of it was mild. In conclusion, cisapride can effectively treat chronic dyspesia which is no response to the treatment of.metoclopramide and domperidone. It is a kind of safe and effective gastroenteric dynamic drug.