摘要
A novel and simple procedure for synthesis of azanucleoside by Mitsunobu reaction between N-（p-nitrobenzyloxycarbonyl）- trans-4-hydroxy-D-proline methyl ester obtained from trans-4-hydroxy-L-proline after six-step reaction and 2-fluoro-6-azidopurine is described, and azanucleoside is fluorinated by new fluridizer 2,2-difluoro-1,3-dimethylimidazolidine （DFI）. All reactions could be carried out under mild condition.
A novel and simple procedure for synthesis of azanucleoside by Mitsunobu reaction between N-（p-nitrobenzyloxycarbonyl）- trans-4-hydroxy-D-proline methyl ester obtained from trans-4-hydroxy-L-proline after six-step reaction and 2-fluoro-6-azidopurine is described, and azanucleoside is fluorinated by new fluridizer 2,2-difluoro-1,3-dimethylimidazolidine （DFI）. All reactions could be carried out under mild condition.
