低分子肝素对血清ⅣC、PⅢP及TGF-β_1水平的影响

The Effects of Low Molecular Weight Heparin on Serum Level of PCⅢ and Type IV Collage and TGF-β_1

目的研究低分子肝素钙抗肝纤维化作用及对血清TGF-β_1水平的影响。方法45例慢性乙型肝炎肝硬化患者,随机分为:①常规治疗组;②常规治疗+低分子肝素钙治疗组,治疗疗程3周。采用放射免疫法检测治疗前后肝纤维化指标;酶联免疫吸附法检测治疗前后血清TGF-β_1水平。结果联合低分子肝素钙可显著改善肝功能;显著降低血清ⅣC、PⅢP及TGF-β_1水平。结论低分子肝素可通过抑制TGF-β_1活性发挥抗纤维化作用。

Objective To study effects of low molecular weight heparin on liver fibrosis and the serum levels of TGF -β1 in patients with chronic hepatitis B virus. Methods 45 patients with chronic hepatitis B virus were randomized into control group （ the routine strategy ） and trial group （ the routine strategy ＋ low molecular weight heparin）. The period of treatment is 3 weeks. Serum hepatic fibrosis indices before and after heparin treatment were examined by RIA , the levels of serum TGF -β1 before and after heparin treatment were examined by ELISA. Results Hepatic functions became significantly better in trial groups, serum P Ⅲ P and type Ⅳ collage levels and the levels of serum TGF -β in trial group decreased significantly after treatment. Conclusions The mechanism of anti - fibrosis action of LMWH may inhibited production of TGF - β1 in patients with HBV.