卵巢移位在年轻宫颈癌根治术中的应用分析

Analysis of ovarian transposition in young women with early stage of cervical cancer

目的:探讨卵巢移位在年轻宫颈癌根治术中应用的可行性和安全性。方法:年轻宫颈癌(年龄40岁以下)36例,临床分期ⅠB～ⅡA期,随机分为两组进行临床观察。其中19例在宫颈癌根治术中行卵巢移位以保留卵巢为观察组;17例在宫颈癌根治术中切除卵巢为对照组。术后应用血FSH、LH、E2及Kuppermann评分测定卵巢功能,随访1～5年。结果:观察组术后5年内卵巢功能基本正常,对照组术后1个月卵巢功能丧失。两组记录生存质量的Kuppermann评分比较差异有非常显著性意义(P<0.01)。而复发率和存活率比较差异无显著性意义(P>0.05)。结论:年轻宫颈癌患者在宫颈癌根治术中行卵巢移位是安全可行的,可保留卵巢功能。

Objective： To investigate the feasibility and safety of ovarian transposition in young wowen with early stage of cervical cancer. Methods： Totally 36 young women （aged 32 - 40 years old） with early stage of cervical cancer （FIGO Ⅰ B - Ⅱ A ） were randomly divided into two groups. Ovarian transposition was performed at the time of radical hysterectomy and pelvic lymphadenectomy in 19 cases, which was designed as the research group; only radical hysterectomy and pelvic lymphadenectomy were done without ovarian transposition in the other 17 cases, as the control group, ovarian function was evaluated by serum FSH, LH, E2 and Kuppermann score system in all of the cases during postoperative 1 - 5 years follow - up. Results： While the patients in control group became climacteric in one month after the operation, normal ovarian function was preserved in the patients of the research group within 1 - 5 years postoperative follow - up. There was a statistically significant difference between research group and control group regarding serum FSH, LH, E2 leval and to Kuppermann score of the patients （ all P〈0. 01） ; also, there was not a statistically significant difference between the two groups regarding recurrence rate and survival rate （all P 〉 0. 05） . Conclusion： Ovarian transposition in young patients undergoing radical hysterectomy and pelvic lymphade- nectomy for early stage of cervical cancer is safe and feasible and may protect ovarian function.