一氧化氮治疗脓毒性ARDS的实验观察

Effects of Inhaled Nitric Oxide on Sepsis Induced ARDS Experiment Observation

16头猪分G1组（ARDS，n=4）、G2组（ARDS＋NO，n=4、G3组（对照＋NO，n＝4）和G4组（对照，n=4）。静脉输注铜绿假单胞菌制备ARDS模型，对照组输注生理盐水。一氧化氮（NO）输送装置释放40ppmNO。结果：G1组发生肺动脉高压，肺内分流增加，低氧血症；G2组肺动脉压较G1组明显下降（P＜0．05）而血压和G1组无差异，分流减少，氧合增加；G3、G4组无明显改变。结论：吸入40ppmNO能选择性降低脓毒性ARDS的肺动脉高压，减少肺内分流，增加氧合。

Sixteen pigs were divided into 4 groups, Group 1 (ARDS,n=4), Group 2(ARDS+N-O,n=4), Group 3(control+No,n=4), Group 4(control, n=4). Intravenouse infusion of Pseudomonas aeruginosa was used to produce pig models of ARDS. Control groups received sterile saline. 40 ppm No were delivered by a nitric oxide (NO) delivery system. Results: Group 1 developed pulmonary artery (PA) hypertension, elevated pulmonary vascular resistance, increased intrapulmonary shunting and hypoxemia; Group 2 PA pressure was significantly reduced while blood pressure was not changed compared with Group 1; intrapulmonary shunting decreased, oxygenation improved. Group 3 and Group 4 were not changed obviously. Conclusions: inhaled 40 ppm NO selectively reduced PA pressure of septic ARDS, decreased intrapulmonary shunting, and improved oxygenation.