CAIMA监控兔出血性休克的疗效评价

The Evaluation of the Treatment of Experimental Hemorrhagic Shock under CAIMA

实验出血性休克家兔在电脑实时监测血压和自动给药系统（CAIMA）监控下，分别应用间羟胺（MET）、MET加多巴胺（DA）和MET加山莨菪碱（654－2）。结果显示：MET仅能暂时升高血压，血乳酸和肌酐值持续上升。MET加DA（5μg·kg－1·min－1）后有扩张血管降低血压作用．但增加MET用量．血乳酸和肌酐值也呈上升态势。MET加654—2（5μg·kg-1·min－1）能使血压稳定，MET用量减少，血乳酸和肌酐值下降。提示MET加654－2方案优于另2种方案。CAIMA系统在实验中能实时监测血压，自动控制MET用量，使血压较稳定地维持在预置水平；效应恒定，MET用量可不断变化，体现了治疗个体化；MET瞬时用量变化有助于正确评价MET加DA和MET加654－2两种联合用药方案的抗休克疗效。

Metaraminol (MET), combined with either dopamine (MET+DA) or anisodamine (MET+654-2) were administered to hemorrhagic shock rabbits respectively under CAIMA (computer assisted instant monitoring drug administration system). The results showed that MET raised the blood pressure (BP) temporarily with a sustained increase in the blood concentration of lactic acid and creatinine content. The addition of DA (5μg·kg-1·min-1) induced a decrease in BP, but with an increase in MET doses, blood concentration of lactic acid and creatinine content were also increased. However, after the addition of 654- 2 (5μg·kg-1·min-1), the BP maintained at constant level while MET doses, lactic acid, and creatinine content were all decreased. Apparently,MET+654-2 for the treatment of hemorrhagic shock rabbits is superior to MET and MET+DA.CAIMA can keep the BP at preset level by continuous monitoring and performing automatic MET administration functions, so it provides variable individual MET doses, which are helpful to evaluate the antishock effects of MET, MET + DA and MET +654- 2.