摘要
目的:对中药芪参复康(QSFK)胶囊抗焦虑作用的神经-免疫调节机制进行初步探讨.方法:采用国际通用的高架十字迷宫模型(EPM)焦虑动物模型,用丁螺环酮(Bus)作对照,观察QSFK对EPM大鼠β-EP,血清NO,IL-1β,IL-6和TNFα的影响.结果:与模型组比较,QSFK和Bus均能降低EPM大鼠血浆β-EP含量(P<0.01),对下丘脑β-EP水平无明显影响;但两组均能升高EPM焦虑模型大鼠血清NO水平(P<0.05);QSFK还可升高EPM大鼠血清IL-1β和TNFα水平,对IL-6含量无明显影响;Bus并不能改变此焦虑模型大鼠的血清细胞因子水平.结论:QSFK降低血浆β-EP含量,提高血清NO浓度和EPM血清IL-1β和TNFα水平,以调节焦虑状态下机体免疫功能紊乱.
AIM： To initially approach the neuro-immune regulation mechanism for antianxiety effect of Chinese medicine Qishenfukang capsule （QSFK）. METHODS： The anxiety animal models with internationally universal elevated plus-maze test（EPM）. With buspirone as control, the effect of QSFK was observed on β-EP, and NO, IL-16, IL-6, TNFα in sera of EPM rats. RESULTS： Compared with the model group, QSFK and buspirone both could significantly reduce the content of β-endorphin in plasma （P 〈0.01 ）, but nonsignificantly effected the content of β-endorphin in hypothalamus; both could significantly increase the level of NO in sera of EPM rats （ P 〈 0.05 ） ; QSFK could significantly increase the levels of IL-1β and TNFα in sera of EPM rats, but nonsignificantly effected the level of IL-6. Buspirone could not effect the levels of cytokines in sera of EPM rats. CONCLUSION： QSFK can adjust immune function under anxiety state through increasing the serum levels of NO, IL-1 and TNF, and decreasing the plasma content of β-endorphin.
出处
《第四军医大学学报》
北大核心
2007年第22期2067-2069,共3页
Journal of the Fourth Military Medical University
基金
全军"十一五"医药卫生科研专项基金(06Z012)
