期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

miRNA与内分泌代谢病 被引量：2

miRNA and endocrine metabolic diseases
下载PDF
导出
摘要 miRNA是近年来发现的一种内源性短序列非编码单链RNA,成熟的miRNA通过两种依赖于序列互补性的机制引起靶mRNA的降解或者抑制其翻译,在基因表达调控中扮演重要的角色。miRNA与内分泌代谢病关系密切,有潜在的生物治疗价值。 MicroRNAs（miRNAs） are recently discovered as endogenous non-coding single-strand RNAs of short sequence.MiRNAs cause degradation or translational repression of the mRNA targets through two mechanisms which depend on sequence complementary,so miRNAs play an important role in the regulation of gene expression.MiRNAs are closely related to the endocrine metabolic diseases,and they have potential biotherapy value.
作者 陈姬 曹仁贤
机构地区 南华大学附属第一医院内分泌科南华大学临床医学研究所
出处 《国际病理科学与临床杂志》 CAS 2007年第5期431-433,共3页 Journal of International Pathology and Clinical Medicine
关键词 MIRNA 内分泌代谢病 胰岛素 microRNA endocrine metabolic diseases insulin
分类号 R58 [医药卫生—内分泌]
  • 相关文献

参考文献22

  • 1Bartel D P. MicroRNAs : genomics, biogenesis, mechanism, and function [ J ]. Cell, 2004,116 ( 2 ) : 281-297.
  • 2Croce C M, Calin G A. MiRNAs,cancer,and stem cell division [J]. Ce11,2005,122(1) :6-7.
  • 3Lee Y, Kim M, Han J, et al. MicroRNA genes are transcribed by RNA polymerase Ⅱ[ J]. EMBO J ,2004,23 (20) :4051-4060.
  • 4Cai X,Hagedorn C H,Cullen B R. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs[J]. RNA,2004,10(12) : 1957-1966.
  • 5Lee Y,Ahn C,Han J,et al. The nuclear RNase Ⅲ Drosha initiates microRNA processing[J]. Nature,2003,425(6956) :415-419.
  • 6Lund E, Guttinger S, Calado A, et al. Nuclear export of microRNA precursors [ J ]. Science ,2004,303 (5654) :95-98.
  • 7Lee Y, Jeon K, Lee J T, et al. MicroRNA maturation : stepwise processing and subcellular localization [ J ]. EMBO J, 2002,21 ( 17 ) : 4663-4670.
  • 8Hutvagner G , McLachlan J, Pasquinelli A E, et al. A cellular function for the RNAintefference enzyme Dicer in the maturation of the let-7 small temporal RNA [ J ]. Science, 2001,293 ( 5531 ) : 834- 838.
  • 9Grishok A, Pasquinelli A, Conte D, et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing [ J ]. Cell, 2001,106( 1 ) :23-24.
  • 10Ketting R F, Sylvia E J, Bernstein F E, et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans [ J ]. Genes Dev, 2001,15 ( 20 ) : 2654-2659.

同被引文献32

  • 1Wang Q,Wang Y, Minto AW, et al. MicroRNA377 is upregulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J, 2008,22 : 4126-4135.
  • 2Ling HY, Ou HS, Feng SD, et al. Changes in microRNA profile and effects of miR320 in insulinresistant 3T3L1 adipocytes. Clin Exp Pharmacol Physiol,2009, [Epub ahead of print].
  • 3Kolfschoten IG, Roggli E, Nesca V, et al. Role and therapeutic potential of microRNAs in diabetes. Diabetes Obes Metab, 2009, Suppl 4 : 118-129.
  • 4Vrabelova Z, Hrocekova Z, Hladikova Z, et al. CD127and FoxP3 + expression on CD25 + CD4 + T regulatory cells upon specific diabetogeneic stimulation in highrisk relatives of type 1 diabetes mellitus patients. Scand J Immunol,2008 ,67 :404-410.
  • 5Zhou X, Jeker LT, Fife RT, et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med, 2005, 205 : 1983-1991.
  • 6Hezova R, Slaby O, Faltejskova P, et al. microRNA342, microRNA191 and microRNA510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cell Immuno1,2010,260: 70-74.
  • 7Roggli E, Britan A, Gattesco S, et al. Involvement of microRNAs in the eytotoxic effects exerted by proinflammatory cytokines on pancreatic {beta}cells. Diabetes,2010, [Epub ahead of print].
  • 8El Ouaamari A, Baroukh N, Martens GA, et al. miR375 targets 3'phosphoinositidedependnt protein kinaseI and regulates glucoseinduced biological responses in pancreatic belaeells. Diabetes, 2008,57 : 2708-2717.
  • 9Lovis P, Roggli E, Laybutt DR, et al. Alterations in microRNA expression contribute to fatty acidinduced pancreatic betacell dysfunction. Diabetes,2008,57 : 2728-2736.
  • 10Tang,X, Muniappan L,Tang G, et al. Identification of glucoseregulated miRNAs from pancreatic β cells reveals a role for miR30d in insulin transcription. RNA ,2009,15:287-293.

引证文献2

二级引证文献1

国际病理科学与临床杂志
2007年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部