头孢哌酮联合阿奇霉素治疗呼吸道细菌感染临床观察

Clinical Observations on the Combined Effects of Cefoperazone and Azithtromycin in the Treatment If Respiratory Bacterial Infection

目的探讨β-内酰胺类与大环内酯类抗生素联合应用的合理性和有效性。方法104例呼吸道细菌感染患者随机分为两组,治疗组用头孢哌酮联合阿奇霉素,对照组单用头孢哌酮。观察两组临床痊愈率,有效率和细菌学疗效。结果治疗组痊愈率63.5%,有效率96.1%,均显著高于对照组(50.0%,80.8%)。细菌清除率治疗组82.7%,对照组75.0%,无显著差异。结论β-内酰胺类与大环内酯类抗生素联合应用不会降低临床疗效,是合理和有效的。

Objective To explore the validity and efficiency of macrolides and β-lactam antibiotics when used simultaneously.Methods 104 patients with respiratory bacterial infection were divided randomly into 2 groups. The treated group used both cefoperazone and azithromycin, the control group were treated only with cefoperazone. Results The treated group yielded a recovery rate of 63.5 % and the effective rate of 96.1%, which were higher than the control group （53.8 % and 80.8 %, P 〉 0.05）. Conclusion A simultaneous use of β- lactam and macrolides in valid and effective, and it doesn＇t decrease the overall clinical effects.