摘要
目的探讨罗库溴铵血浆-效应室平衡速率常数（Ke0）的两种计算方法的差异性。方法22例ASAⅠ-Ⅱ级择期手术患者，A组（n=11）持续输注罗库溴铵0．03mg·kg^-1·min^-1直至4个成串刺激（TOF）降至20％-30％，B组（n=11）单次注射罗库溴铵2mg·kg^-1。A组血浆药物浓度用Sheiner等报道的药代动力学参数模拟计算，预测效应根据药代动力学-药效学关系公式换算，Ke0通过S型曲线拟合计算。B组采用Minto等提出的方法计算。结果A、B组的Ke0平均值分别为（0．200-±0．049）min^-1和（0．111±0．019）min^-1（P〈0．01）。结论两种方法计算的罗库溴铵Ke0不同，有待进一步研究确定哪一个更适合于临床应用。
Objective To compare two methods to calcaluate the pharmacokinetic parameter Ke0 of rocuronium so as to improve the accuracy of target - controlled effect - site concentration infusion. Methods Twenty - two ASA Ⅰ - Ⅱ patients scheduled for elective surgery were divided into two groups （ n = 11 each）. Group A was given continuous infusion of rocuronium 0.03 mg·kg^-1·min^-1 up to TOF ratio of 20% -30%. The theoretical plasma concentration versus time was calculated for all patients on the basis of the pharmacokinetic models described by Sheiner et al. Predicted effect versus time was calculated by following the pharmacokinetic - pharmacodynarnic link model. The Ke0 was estimated by fitting a sigmoid cure. Group B was given the drug in a bolus of 2 mg·kg^-1 and the Ke0 was calculated according to the method reported by Minto et al. Results The Keo was（0. 200±0.049） min^-1 and （0. 111±0.019）min^-1 in group A and group B respectively, showing significant difference （ P 〈 0.01 ）. Conclusion As the values of rocuronium Ke0 vary with the calculating methods employed, it is necessary to further study which method is appropriate for clinical application.
出处
《徐州医学院学报》
CAS
2007年第11期725-727,共3页
Acta Academiae Medicinae Xuzhou
