高血压病患者抗心磷脂抗体测定的临床意义

Measurement of Anticardiolipin Antibodies and Its Significance in Hypertension

目的：探讨抗心磷脂抗体（ＡＣＬＡ）检测在高血压病患者中的临床意义。方法：采用酶联免疫吸附法检测１４５例高血压病患者和４０名健康者，计算标本的结合指数和阳性率。结果：高血压病Ⅱ期组患者ＡＣＬＡ的平均结合指数显著高于健康对照组。高血压病组的ＡＣＬＡ阳性４０例（２７．６％），有脑梗塞的高血压病组ＡＣＬＡ阳性率高于无脑梗塞组。结论：高血压病患者存在自身免疫，测定ＡＣＬＡ对预测高血压病的程度和防治缺血性中风的发生有一定的临床意义。

Objective:To explore the clinical significance of circulating anticardiolipin antibodies(ACLA) in essential hypertension(EH). Methods:IgG,IgM and IgA ACLA were measured in 145 patients with EH(104 hypertension,41 cerebral infarction) and 40 healthy controls by an enzyme linked immunoabsorbent assay. Results:The average binding index of ACLA was significantly higher in patients than in controls (p<0.05￣0.01),40 EH patients (27.6%) had a positive ACLA. The incidence rate of positive ACLA was higher in patients with cerebral infarction than in those with noncerebral infarction( p <0.001). Conclusion:The results suggest that circulating ACLA might have some clinical significance in prognosis.